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KMID : 0385620150230010035
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Korean Journal of Psychopathology
2015 Volume.23 No. 1 p.35 ~ p.49
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Determinants of Quality of Life in Patients with Autoimmune Thyroid Diseases
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Lee Yun-Na
Cheon Jin-Sook
Choi Young-Sik
Oh Byoung-Hoon
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Abstract
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Objectives : The aims of this study were to know whether quality of life (QoL) was lowered in patients with autoimmune thyroid disorders, and to identify influencing factors on their QoL.
Methods : Demographic and clinical data were obtained by structured interviews for healthy controls (N=40) and patients with autoimmune thyroid disorders (N=41). The measurements of QoL and depression were also performed using Korean Version of WHOQOL-BREF and Korean Version of Hamilton Deression Rating Scale.
Results : 1) The total QoL scores, general health, domain 1 (physical health domain), domain 2 (psychological domain), domain 3 (social relationship domain) and domain 4 (environmental domain) were significantly lower in patients with autoimmune thyroid disorder than those of healthy controls (p<0.001, respectively). 2) Overall QoL had negative correlation with K-HDRS and economic status, and general health had negative correlation with K-HDRS (p<0.01, respectively). Total QoL scores had positive correlation with education, and had negative correlation with K-HDRS and economic status (p<0.01, respectively). Physical health domain had negative correlation with K-HDRS (p<0.01), and had positive correlation with antimicrosomal antibodies (p<0.05). Psychological domain had positive correlation with TSH (p<0.05), and had negative correlation with K-HDRS (p<0.01) and T3 (p<0.05). Social relationship domain had negative correlation with K-HDRS (p<0.01). Environmental domain had positive correlation with education, and had negative correlation with economic status (p<0.01, respectively). 3) According to regression analysis, antimicrosomal antibodies influenced negatively on the total QoL scores (β=-0.002), and positively on the overall QoL (β=0.037), general health (β=0.023), physical health domain (β=0.003), psychological domain (β=0.006), social relationship domain(β=0.013) and environmental domain (β=0.004)(p<0.01, respectively).
Conclusion : The thyroid antimicosomal antibodies seemed to be the most important determinant of QoL in patients with autoimmune thyroid disorders.
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KEYWORD
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Autoimmune thyroid disorder, Quality of life, Depression, Education, Economic status, Antimicrosomal antibodies
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